B cell profiling in malaria reveals expansion and remodelling of CD11c+ B cell subsets.

ABSTRACT: Humoral immunity is important in limiting clinical disease in malaria, yet the longitudinal B cell response to infection remains unclear. We performed a 1-year prospective study in patients treated for acute P. falciparum malaria for the first time, or with previous exposure to the disease. Using an unbiased exploratory approach with mass cytometry, followed by targeted flow cytometry, we found that ~80% of mature B cells that proliferated in response to acute infection expressed CD11c. Only ~40% of CD11c+ B cells displayed an atypical B cell phenotype, with the remaining cells primarily made up of activated- and resting memory B cells. The CD11c+ B cells expanded rapidly following infection, with previous exposure to malaria resulting in a significantly larger increase compared to individ

SUBMITTER: Sundling C 

PROVIDER: S-EPMC6538354 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature