Vaccine safety in HIV-infected adults within the Vaccine Safety Datalink Project.

ABSTRACT:

Objectives

We evaluate safety of routine vaccination among adults infected with human immunodeficiency virus (HIV) in five healthcare organizations in the United States.

Methods

We conducted a retrospective cohort study of HIV-infected adults who received inactivated influenza vaccines, hepatitis B vaccines, pneumococcal vaccines, or tetanus, diphtheria, and acellular pertussis vaccines between 2002 and 2013. We conducted self-controlled case series analysis to estimate the relative risk (RR) for 11 pre-specified adverse events (AEs) requiring medical attention.

Results

Among 20,417 HIV-infected adults (90.2% male), a total of 137,674 vaccine doses were administered. Based on ICD-9 codes, we detected an increased risk of cellulitis and infection (RR: 1.18, 95% CI: 1.0

SUBMITTER: Hechter RC 

PROVIDER: S-EPMC6538462 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature