MERIT: Systematic Analysis and Characterization of Mutational Effect on RNA Interactome Topology.

ABSTRACT: The interaction between RNA-binding proteins (RBPs) and RNA plays an important role in regulating cellular function. However, decoding genome-wide protein-RNA regulatory networks as well as how cancer-related mutations impair RNA regulatory activities in hepatocellular carcinoma (HCC) remains mostly undetermined. We explored the genetic alteration patterns of RBPs and found that deleterious mutations are likely to occur on the surface of RBPs. We then constructed protein-RNA interactome networks by integration of target binding screens and expression profiles. Network analysis highlights regulatory principles among interacting RBPs. In addition, somatic mutations selectively target functionally important genes (cancer genes, core fitness genes, or conserved genes) and perturb the RBP-gene

SUBMITTER: Li Y 

PROVIDER: S-EPMC6538468 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature