Decarboxylative Trifluoromethylation of Aliphatic Carboxylic Acids.

ABSTRACT: Herein we disclose an efficient method for the conversion of carboxylic acids to trifluoromethyl groups via the combination of photoredox and copper catalysis. This transformation tolerates a wide range of functionality including heterocycles, olefins, alcohols, and strained ring systems. To demonstrate the broad potential of this new methodology for late-stage functionalization, we successfully converted a diverse array of carboxylic acid-bearing natural products and medicinal agents to the corresponding trifluoromethyl analogues.

SUBMITTER: Kautzky JA 

PROVIDER: S-EPMC6538506 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature