Needleless intradermal vaccination for foot-and-mouth disease induced granuloma-free effective protection in pigs.

ABSTRACT: Vaccination is one of the most effective ways of controlling and preventing foot-and-mouth disease (FMD) outbreaks. The effective prevention of this disease requires the use of high-quality vaccines to meet the criteria that enable customers to use them simply. The administration of FMD vaccines containing oil-based adjuvants in pigs can induce the formation of granuloma in the muscle of the vaccinated, which makes these vaccines a less preferable option. Therefore, it is important to establish an FMD vaccine and vaccine delivery tool that offers better immunity and safer application. This study compared the immune responses of intramuscular and needleless intradermal vaccination in pigs. When the same amount of an FMD virus (FMDV) antigen was administered to pigs, both the intradermally a

SUBMITTER: Hwang JH 

PROVIDER: S-EPMC6538519 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature