Deciphering host lysosome-mediated elimination of Plasmodium berghei liver stage parasites.

ABSTRACT: Liver stage Plasmodium parasites reside in a parasitophorous vacuole (PV) that associates with lysosomes. It has previously been shown that these organelles can have beneficial as well as harmful effects on the parasite. Yet it is not clear how the association of lysosomes with the parasite is controlled and how interactions with these organelles lead to the antagonistic outcomes. In this study we used advanced imaging techniques to characterize lysosomal interactions with the PV. In host cells harboring successfully developing parasites we observed that these interaction events reach an equilibrium at the PV membrane (PVM). In a population of arrested parasites, this equilibrium appeared to shift towards a strongly increased lysosomal fusion with the PVM witnessed by strong PVM labeling w

SUBMITTER: Niklaus L 

PROVIDER: S-EPMC6538699 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature