Ontology highlight
ABSTRACT:
SUBMITTER: Martinez-Velez N
PROVIDER: S-EPMC6538754 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Nature communications 20190528 1
Pediatric high-grade glioma (pHGG) and diffuse intrinsic pontine gliomas (DIPGs) are aggressive pediatric brain tumors in desperate need of a curative treatment. Oncolytic virotherapy is emerging as a solid therapeutic approach. Delta-24-RGD is a replication competent adenovirus engineered to replicate in tumor cells with an aberrant RB pathway. This virus has proven to be safe and effective in adult gliomas. Here we report that the administration of Delta-24-RGD is safe in mice and results in a ...[more]