CGRP signalling inhibits NO production through pannexin-1 channel activation in endothelial cells.

ABSTRACT: Blood flow distribution relies on precise coordinated control of vasomotor tone of resistance arteries by complex signalling interactions between perivascular nerves and endothelial cells. Sympathetic nerves are vasoconstrictors, whereas endothelium-dependent NO production provides a vasodilator component. In addition, resistance vessels are also innervated by sensory nerves, which are activated during inflammation and cause vasodilation by the release of calcitonin gene-related peptide (CGRP). Inflammation leads to superoxide anion (O₂^{• -}) formation and endothelial dysfunction, but the involvement of CGRP in this process has not been evaluated. Here we show a novel mechanistic relation between perivascular sensory nerve-derived CGRP and the development of endothelial

SUBMITTER: Gaete PS 

PROVIDER: S-EPMC6538758 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature