A Substrate-Activated Efflux Pump, DesABC, Confers Zeamine Resistance to Dickeya zeae.

ABSTRACT: Zeamines are a family of polyamino phytotoxins produced by Dickeya zeae EC1. These phytotoxins are also potent antibiotics against a range of microorganisms. To understand how D. zeae EC1 can protect itself from the antimicrobial activity of zeamines, we tested whether the ABC transporter genes within the zms (zeamine synthesis) gene cluster were related to zeamine resistance. Our results ruled out the possible involvement of these ABC transporters in zeamine resistance and instead unveiled an RND (resistance-nodulation-cell division) efflux pump, DesABC, which plays an important role in zeamine resistance in D. zeae EC1. The desAB genes are located next to the zms gene cluster, but desC is at a distant location in the bacterial genome. Null

SUBMITTER: Liang Z 

PROVIDER: S-EPMC6538784 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature