Infection-Induced Intestinal Dysbiosis Is Mediated by Macrophage Activation and Nitrate Production.

ABSTRACT: Oral infection of C57BL/6J mice with Toxoplasma gondii results in a marked bacterial dysbiosis and the development of severe pathology in the distal small intestine that is dependent on CD4⁺ T cells and interferon gamma (IFN-γ). This dysbiosis and bacterial translocation contribute to the development of ileal pathology, but the factors that support the bloom of bacterial pathobionts are unclear. The use of microbial community profiling and shotgun metagenomics revealed that Toxoplasma infection induces a dysbiosis dominated by Enterobacteriaceae and an increased potential for nitrate respiration. In vivo experiments using bacterial metabolic mutants revealed that during this infection, host-derived nitrate supports the expansion of Enterobacteriace

SUBMITTER: Wang S 

PROVIDER: S-EPMC6538788 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature