Amide Proton Transfer Contrast Distribution in Different Brain Regions in Young Healthy Subjects.

ABSTRACT:

Objectives

To define normal signal intensity values of amide proton transfer-weighted (APTw) magnetic resonance (MR) imaging in different brain regions.

Materials and methods

Twenty healthy subjects (9 females, mean age 29 years, range 19 - 37 years) underwent MR imaging at 3 Tesla. 3D APTw (RF saturation B_1,rms = 2 μT, duration 2 s, 100% duty cycle) and 2D T2-weighted turbo spin echo (TSE) images were acquired. Postprocessing (image fusion, ROI measurements of APTw intensity values in 22 different brain regions) was performed and controlled by two independent neuroradiologists. Values were measured separately for each brain hemisphere. A subject was scanned both in prone and supine position to investigate differences between hemispheres. A mixed model on a 5% sig

SUBMITTER: Sartoretti T 

PROVIDER: S-EPMC6538817 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature