Raman spectroscopy for accurately characterizing biomolecular changes in androgen-independent prostate cancer cells.

ABSTRACT: Metastatic prostate cancer resistant to hormonal manipulation is considered the advanced stage of the disease and leads to most cancer-related mortality. With new research focusing on modulating cancer growth, it is essential to understand the biochemical changes in cells that can then be exploited for drug discovery and for improving responsiveness to treatment. Raman spectroscopy has a high chemical specificity and can be used to detect and quantify molecular changes at the cellular level. Collection of large data sets generated from biological samples can be employed to form discriminatory algorithms for detection of subtle and early changes in cancer cells. The present study describes Raman finger printing of normal and metastatic hormone-resistant prostate cancer cells including analy

SUBMITTER: Corsetti S 

PROVIDER: S-EPMC6538931 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature