Tau PET With ¹⁸F-THK-5351 Taiwan Patients With Familial Alzheimer's Disease With the APP p.D678H Mutation.

ABSTRACT: Background: Brain ¹⁸F-AV-45 amyloid positron emission tomography (PET) in Taiwanese patients with familial Alzheimer's disease with the amyloid precursor protein (APP) p.D678H mutation tends to involve occipital and cerebellar cortical areas. However, tau pathology in patients with this specific Taiwan mutation remains unknown. In this study, we aimed to study the Tau PET images in these patients. Methods: Clinical features, brain magnetic resonance imaging/computed tomography (MRI/CT), and brain ¹⁸F-THK-5351 PET were recorded in five patients with the APP p.D678H mutation and correlated with brain ¹⁸F-AV-45 PET images. We also compared the tau deposition patterns among five patients with familial mild cognitive impairment (fMCI), six patients

SUBMITTER: Huang CC 

PROVIDER: S-EPMC6538951 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature