Estimates of all cause mortality and cause specific mortality associated with proton pump inhibitors among US veterans: cohort study.

ABSTRACT:

Objective

To estimate all cause mortality and cause specific mortality among patients taking proton pump inhibitors (PPIs).

Design

Longitudinal observational cohort study.

Setting

US Department of Veterans Affairs.

Participants

New users of PPIs (n=157 625) or H2 blockers (n=56 842).

Main outcome measures

All cause mortality and cause specific mortality associated with taking PPIs (values reported as number of attributable deaths per 1000 patients taking PPIs).

Results

There were 45.20 excess deaths (95% confidence interval 28.20 to 61.40) per 1000 patients taking PPIs. Circulatory system diseases (number of attributable deaths per 1000 patients taking PPIs 17.47, 95% confidence interval 5.47 to 28.80), neoplasms (12.94, 1.24 to 24.28), infectious

SUBMITTER: Xie Y 

PROVIDER: S-EPMC6538974 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature