Gut Microbiome Alterations During HIV/SIV Infection: Implications for HIV Cure.

ABSTRACT: Gut mucosal damage, associated with Human Immunodeficiency Virus-1 (HIV) infection, is characterized by depletion in CD4⁺ T cells and persistent immune activation as a result of early epithelial barrier disruption and systemic translocation of microbial products. Unique approaches in studying both HIV infection in human patients and Simian Immunodeficiency Virus (SIV) infection in rhesus macaques have provided critical evidence for the pathogenesis and treatment of HIV/AIDS. While there is vast resemblance between SIV and HIV infection, the development of gut dysbiosis attributed to HIV infection in chronically infected patients has not been consistently reported in SIV infection in the non-human primate model of AIDS, raising concerns for the translatability of gut microbiome s

SUBMITTER: Crakes KR 

PROVIDER: S-EPMC6539195 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature