25-Hydroxyvitamin D Inhibits Hepatitis C Virus Production in Hepatocellular Carcinoma Cell Line by a Vitamin D Receptor-Independent Mechanism.

ABSTRACT: Previously, we have reported that the active vitamin D metabolite, calcitriol and vitamin D₃ (cholecalciferol), both remarkably inhibit hepatitis C virus production. The mechanism by which vitamin D₃ exerts its effect is puzzling due to the low levels of calcitriol produced in vitamin D₃-treated Huh7.5 cells. In this study, we aimed to explore the mechanism of vitamin D₃ anti-hepatitis C virus effect. We show that vitamin D₃ activity is not mediated by its metabolic conversion to calcitriol, but may be due to its primary metabolic product 25(OH)D₃. This is inferred from the findings that 25(OH)D₃ could inhibit hepatitis C virus production in our system, and that adequate concentrations needed to exert this effect

SUBMITTER: Ravid A 

PROVIDER: S-EPMC6539257 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature