Mapping Semaphorins and Netrins in the Pathogenesis of Human Thoracic Aortic Aneurysms.

ABSTRACT: Thoracic aortic aneurysm (TAA) is a complex life-threatening disease characterized by extensive extracellular matrix (ECM) fragmentation and persistent inflammation, culminating in a weakened aorta. Although evidence suggests defective canonical signaling pathways in TAA, the full spectrum of mechanisms contributing to TAA is poorly understood, therefore limiting the scope of drug-based treatment. Here, we used a sensitive RNA sequencing approach to profile the transcriptomic atlas of human TAA. Pathway analysis revealed upregulation of key matrix-degrading enzymes and inflammation coincident with the axonal guidance pathway. We uncovered their novel association with TAA and focused on the expression of Semaphorins and Netrins. Comprehensive analysis of this pathway showed that several mem

SUBMITTER: Alebrahim D 

PROVIDER: S-EPMC6539328 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature