Modeling the Tertiary Structure of the Rift Valley Fever Virus L Protein.

ABSTRACT: A tertiary structure governs, to a great extent, the biological activity of a protein in the living cell and is consequently a central focus of numerous studies aiming to shed light on cellular processes central to human health. Here, we aim to elucidate the structure of the Rift Valley fever virus (RVFV) L protein using a combination of in silico techniques. Due to its large size and multiple domains, elucidation of the tertiary structure of the L protein has so far challenged both dry and wet laboratories. In this work, we leverage complementary perspectives and tools from the computational-molecular-biology and bioinformatics domains for constructing, refining, and evaluating several atomistic structural models of the L protein that are physically realistic. All computed models have ver

SUBMITTER: Gogovi GK 

PROVIDER: S-EPMC6539450 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature