Dynamics of Dual Specificity Phosphatases and Their Interplay with Protein Kinases in Immune Signaling.

ABSTRACT: Dual specificity phosphatases (DUSPs) have a well-known role as regulators of the immune response through the modulation of mitogen-activated protein kinases (MAPKs). Yet the precise interplay between the various members of the DUSP family with protein kinases is not well understood. Recent multi-omics studies characterizing the transcriptomes and proteomes of immune cells have provided snapshots of molecular mechanisms underlying innate immune response in unprecedented detail. In this study, we focus on deciphering the interplay between members of the DUSP family with protein kinases in immune cells using publicly available omics datasets. Our analysis resulted in the identification of potential DUSP-mediated hub proteins including MAPK7, MAPK8, AURKA, and IGF1R. Furthermore, we analyzed

SUBMITTER: Subbannayya Y 

PROVIDER: S-EPMC6539644 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature