Altered haemodynamics causes aberrations in the epicardium.

ABSTRACT: During embryo development, the heart is the first functioning organ. Although quiescent in the adult, the epicardium is essential during development to form a normal four-chambered heart. Epicardial-derived cells contribute to the heart as it develops with fibroblasts and vascular smooth muscle cells. Previous studies have shown that a heartbeat is required for epicardium formation, but no study to our knowledge has shown the effects of haemodynamic changes on the epicardium. Since the aetiologies of many congenital heart defects are unknown, we suggest that an alteration in the heart's haemodynamics might provide an explanatory basis for some of them. To change the heart's haemodynamics, outflow tract (OFT) banding using a double overhang knot was performed on HH21 chick embryos, with har

SUBMITTER: Perdios C 

PROVIDER: S-EPMC6539700 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature