Modulation of SUR1 K_ATP Channel Subunit Activity in the Peripheral Nervous System Reduces Mechanical Hyperalgesia after Nerve Injury in Mice.

ABSTRACT: The ATP-sensitive K⁺ channel (K_ATP) is involved in hypersensitivity during chronic pain and is presumed to be a downstream target of mu opioid receptors. Multiple subtypes of K_ATP channels exist in the peripheral and central nervous system and their activity may be inversely correlated to chronic pain phenotypes in rodents. In this study, we investigated the different K_ATP channel subunits that could be involved in neuropathic pain in mice. In chronic pain models utilizing spinal nerve ligation, SUR1 and Kir6.2 subunits were found to be significantly downregulated in dorsal root ganglia and the spinal cord. Local or intrathecal administration of SUR1-K_ATP channel subtype agonists resulted in analgesia after spinal nerve ligation but no

SUBMITTER: Luu W 

PROVIDER: S-EPMC6539735 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature