Relationship of Iron Metabolism and Short-Term Cuprizone Treatment of C57BL/6 Mice.

ABSTRACT: One of the models to investigate the distinct mechanisms contributing to neurodegeneration in multiple sclerosis is based on cuprizone (CZ) intoxication. CZ is toxic to mature oligodendrocytes and produces demyelination within the central nervous system but does not cause direct neuronal damage. The CZ model is suitable for better understanding the molecular mechanism of de- and remyelination processes of oligodendrocytes. CZ is a copper chelating agent and it also affects the iron metabolism in brain and liver tissues. To determine the early effect of CZ treatment on iron homeostasis regulation, cytosolic and mitochondrial iron storage, as well as some lipid metabolism genes, we investigated the expression of respective iron homeostasis and lipid metabolism genes of the corpus callosum (C

SUBMITTER: Pandur E 

PROVIDER: S-EPMC6539941 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature