Dataset Information

Sesquiterpenoids and Their Anti-Inflammatory Activity: Evaluation of Ainsliaea yunnanensis.

ABSTRACT: Four new sesquiterpenoids (1-4) and six known sesquiterpenoids (5-10), were isolated from the EtOAc phase of the ethanolic extract of Ainsliaea yunnanensis. Their structures were established by spectroscopic methods, including 1-D, 2-D NMR and HPLC-MS. All compounds were tested for their anti-inflammatory effect by the inhibition of the activity of NLRP3 inflammasome by blocking the self-slicing of pro-caspase-1, which is induced by nigericin, then the secretion of mature IL-1β, mediated by caspase-1, was suppressed. Unfortunately none of the compounds showed an anti-inflammatory effect.

SUBMITTER: Li J

PROVIDER: S-EPMC6539984 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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Sesquiterpenoids and Their Anti-Inflammatory Activity: Evaluation of Ainsliaea yunnanensis.

Li Jinjie J Li Xiuting X Wang Xin X Zhong Xiangjian X Ji Linlin L Guo Zihan Z Liu Yiran Y Shang Xiaoya X

Molecules (Basel, Switzerland) 20190501 9

Four new sesquiterpenoids (1-4) and six known sesquiterpenoids (5-10), were isolated from the EtOAc phase of the ethanolic extract of Ainsliaea yunnanensis. Their structures were established by spectroscopic methods, including 1-D, 2-D NMR and HPLC-MS. All compounds were tested for their anti-inflammatory effect by the inhibition of the activity of NLRP3 inflammasome by blocking the self-slicing of pro-caspase-1, which is induced by nigericin, then the secretio ...[more]

PMID: 31052362

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Dataset Information

Sesquiterpenoids and Their Anti-Inflammatory Activity: Evaluation of Ainsliaea yunnanensis.

Publications

Sesquiterpenoids and Their Anti-Inflammatory Activity: Evaluation of <i>Ainsliaea yunnanensis</i>.

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