Sonic Hedgehog Signaling Is Required for Cyp26 Expression during Embryonic Development.

ABSTRACT: Deciphering how signaling pathways interact during development is necessary for understanding the etiopathogenesis of congenital malformations and disease. In several embryonic structures, components of the Hedgehog and retinoic acid pathways, two potent players in development and disease are expressed and operate in the same or adjacent tissues and cells. Yet whether and, if so, how these pathways interact during organogenesis is, to a large extent, unclear. Using genetic and experimental approaches in the mouse, we show that during development of ontogenetically different organs, including the tail, genital tubercle, and secondary palate, Sonic hedgehog (SHH) loss-of-function causes anomalies phenocopying those induced by enhanced retinoic acid signaling and that SHH is required to preve

SUBMITTER: El Shahawy M 

PROVIDER: S-EPMC6540044 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature