Deprescribing in the Pharmacologic Management of Delirium: A Randomized Trial in the Intensive Care Unit.

ABSTRACT:

Objective

Benzodiazepines and anticholinergics are risk factors for delirium in the intensive care unit (ICU). We tested the impact of a deprescribing intervention on short-term delirium outcomes.

Design

Multisite randomized clinical trial.

Setting

ICUs of three large hospitals.

Participants

Two hundred adults aged 18 years or older and admitted to an ICU with delirium, according to the Richmond Agitation-Sedation Scale and the Confusion Assessment Method for the ICU (CAM-ICU). Participants had a contraindication to haloperidol (seizure disorder or prolonged QT interval) or preference against haloperidol as a treatment for delirium, and were excluded for serious mental illness, stroke, pregnancy, or alcohol withdrawal. Participants were randomized to a deprescr

SUBMITTER: Campbell NL 

PROVIDER: S-EPMC6540083 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature