Identifying lncRNA-mediated regulatory modules via ChIA-PET network analysis.

ABSTRACT:

Background

Although several studies have provided insights into the role of long non-coding RNAs (lncRNAs), the majority of them have unknown function. Recent evidence has shown the importance of both lncRNAs and chromatin interactions in transcriptional regulation. Although network-based methods, mainly exploiting gene-lncRNA co-expression, have been applied to characterize lncRNA of unknown function by means of 'guilt-by-association', no strategy exists so far which identifies mRNA-lncRNA functional modules based on the 3D chromatin interaction graph.

Results

To better understand the function of chromatin interactions in the context of lncRNA-mediated gene regulation, we have developed a multi-step graph analysis approach to examine the RNA polymerase II ChIA-PET chromatin

SUBMITTER: Thiel D 

PROVIDER: S-EPMC6540383 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature