TelomereHunter - in silico estimation of telomere content and composition from cancer genomes.

ABSTRACT:

Background

Establishment of telomere maintenance mechanisms is a universal step in tumor development to achieve replicative immortality. These processes leave molecular footprints in cancer genomes in the form of altered telomere content and aberrations in telomere composition. To retrieve these telomere characteristics from high-throughput sequencing data the available computational approaches need to be extended and optimized to fully exploit the information provided by large scale cancer genome data sets.

Results

We here present TelomereHunter, a software for the detailed characterization of telomere maintenance mechanism footprints in the genome. The tool is implemented for the analysis of large cancer genome cohorts and provides a variety of diagnostic diagrams as well

SUBMITTER: Feuerbach L 

PROVIDER: S-EPMC6540518 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature