Contribution of LTi and T_H17 cells to B cell aggregate formation in the central nervous system in a mouse model of multiple sclerosis.

ABSTRACT:

Background

In a subgroup of patients suffering from progressive multiple sclerosis (MS), which is an inflammation-mediated neurodegenerative disease of the central nervous system (CNS), B cell aggregates were discovered within the meninges. Occurrence of these structures was associated with a more severe disease course and cortical histopathology. We have developed the B cell-dependent MP4-induced experimental autoimmune encephalomyelitis (EAE) as a mouse model to mimic this trait of the human disease. The aim of this study was to determine a potential role of lymphoid tissue inducer (LTi) and T_H17 cells in the process of B cell aggregate formation in the MP4 model.

Methods

We performed flow cytometry of cerebellar and splenic tissue of MP4-immunized mice in the a

SUBMITTER: Schropp V 

PROVIDER: S-EPMC6540524 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature