Clinical significance of C4d deposition in renal tissues from patients with primary Sjogren's syndrome-a preliminary study.

ABSTRACT:

Background

To evaluate renal expression of C4d, a complement component in the classical/mannose binding lectin (MBL) pathway, in patients with primary Sjögren's syndrome (pSS)-associated renal impairments.

Methods

We retrospectively reviewed the clinical and pathological data from 39 patients with pSS presenting with renal impairments. C4d was examined in paraffin-embedded biopsy tissues using immunohistochemistry. Glomerular C4d positive was defined when > 75% glomeruli were globally stained. Tubulointerstitial C4d (TI-C4d) were scored semi-quantitatively as 0 (absent), 1 (spotty or weak), 2 (patchy) and 3 (diffuse). A TI-C4d score ≥ 2 was considered TI-C4d positive and included in the TI-C4d⁺ group and vice versa. Peritubular capillary (PTC) C4d was scored as 0

SUBMITTER: Xia W 

PROVIDER: S-EPMC6540533 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature