Radiotherapy resistance in chondrosarcoma cells; a possible correlation with alterations in cell cycle related genes.

ABSTRACT:

Background

Conventional chondrosarcomas are malignant cartilage tumors considered radioresistant. Nevertheless, retrospective series show a small but significant survival benefit for patients with locally advanced disease treated with radiotherapy. And, in daily practice when considered inoperable their irradiation is an accepted indication for proton beam radiotherapy. Therefore, we investigated the sensitivity of chondrosarcoma cell lines and -tissue samples towards radiotherapy and screened for biomarkers to identify predictors of radiosensitivity.

Methods

Proliferation and clonogenic assays were performed in chondrosarcoma cell lines after γ-radiation in combination with mutant IDH1 inhibitor AGI-5198. In addition, glutathione levels were measured using mass spectrometry

SUBMITTER: de Jong Y 

PROVIDER: S-EPMC6540537 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature