Preconceptional, Gestational, and Lactational Exposure to an Unconventional Oil and Gas Chemical Mixture Alters Energy Expenditure in Adult Female Mice.

ABSTRACT: Previous studies conducted in our laboratory have found altered adult health outcomes in animals with prenatal exposure to environmentally relevant levels of unconventional oil and gas (UOG) chemicals with endocrine-disrupting activity. This study aimed to examine potential metabolic health outcomes following a preconception, prenatal and postnatal exposure to a mixture of 23 UOG chemicals. Prior to mating and from gestation day 1 to postnatal day 21, C57BL/6J mice were developmentally exposed to a laboratory-created mixture of 23 UOG chemicals in maternal drinking water. Body composition, spontaneous activity, energy expenditure, and glucose tolerance were evaluated in 7-month-old female offspring. Neither body weight nor body composition differed in 7-month female mice. However, females exposed to 1.5 and 150 ?g/kg/day UOG mix had lower total and resting energy expenditure within the dark cycle. In the light cycle, the 1,500 ?g//kg/day group had lower total energy expenditure and the 1.5 ?g/kg/day group had lower resting energy expenditure. Females exposed to the 150 ?g/kg/day group had lower spontaneous activity in the dark cycle, and females exposed to the 1,500 ?g/kg/day group had lower activity in the light cycle. This study reports for the first time that developmental exposure to a mixture of 23 UOG chemicals alters energy expenditure and spontaneous activity in adult female mice.

SUBMITTER: Balise VD 

PROVIDER: S-EPMC6540741 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature