Evaluation of rs1982073 polymorphism of transforming growth factor-β1 in glioblastoma.

ABSTRACT:

Background

Glioblastoma (GBM) is the most common and invasive form of primary malignant brain tumors, with a survival rate of about 1 year. Transforming growth factor-β1 (TGF-β1) plays a very important role in tissue homeostasis and cancers. It seems that polymorphism of T29C (L10P, rs1982073, or rs1800470), which has been studied in various cancers such as breast and colon, creates the significant differences plays an important role in GBM prognosis and treatment. In this study, we evaluated the effect of T29C (rs1982073) polymorphism of TGF-β1 gene in GBM.

Materials and methods

This study was conducted on 100 cases of GBM including 47 paraffin-embedded brain tissue samples and 53 blood samples from another 53 GBM patients, who was under therapy, and 150 were control

SUBMITTER: Sadeghi Y 

PROVIDER: S-EPMC6540769 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature