Gene expression pattern of CCL2, CCL3, and CXCL8 in patients with bipolar disorder.

ABSTRACT:

Background

Bipolar disorder (BD) is one of the most important psychiatric disorders in the world. There is evidence suggesting the role of inflammatory mediators such as chemokines in the etiology of BD. The objective of the current study was to evaluate the gene expression of CCL2, CCL3, and CXCL8 in patients with BD and compare them to healthy controls.

Materials and methods

A total of 48 patients with confirmed BD and 48 healthy controls enrolled in this study. All patients were recruited from April to August 2016 at Ibn-Sina Psychiatric Hospital, Mashhad University of Medical Sciences, Mashhad, Iran. RNA was extracted from the whole blood samples and then cDNA was synthesized. Gene expression of CCL2, CCL3, and CXCL8 was measured

SUBMITTER: Ghoryani M 

PROVIDER: S-EPMC6540773 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature