Clinical trials involving carbon-ion radiation therapy and the path forward.

ABSTRACT: To describe the international landscape of clinical trials in carbon-ion radiotherapy (CIRT), the authors reviewed the current status of 63 ongoing clinical trials (median, 47 participants) involving CIRT identified from the US clinicaltrials.gov trial registry and the World Health Organization International Clinical Trials Platform Registry. The objectives were to evaluate the potential for these trials to define the role of this modality in the treatment of specific cancer types and identify the major challenges and opportunities to advance this technology. A significant body of literature suggested the potential for advantageous dose distributions and, in preclinical biologic studies, the enhanced effectiveness for CIRT compared with photons and protons. In addition, clinical evidence f

SUBMITTER: Lazar AA 

PROVIDER: S-EPMC6540799 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature