Bone Mass in Newborns Assessed by DXA - A Systematic Review and Meta-analysis.

ABSTRACT:

Purpose

Peak bone mass - a key determinant of osteoporotic fractures result from bone accretion starting form intrauterine life to early adulthood. Optimal skeletal growth in-utero and infancy may offer protection against osteoporosis in adult life. We attempted to pool the data from available literature to get a consensus on average bone mass among healthy newborns (age ≤30 days after birth).

Methods

Systematic review was conducted (PRISMA guidelines) to generate pooled estimates of bone mass parameters at whole body (WB) and lumbar spine (LS), based on both fixed and random effect models of meta-analyses. Two investigators independently carried out a comprehensive literature search using PubMed, Google Scholar and Embase. Meta-regression was applied to further explore caus

SUBMITTER: Ramot R 

PROVIDER: S-EPMC6540894 | biostudies-literature | 2019 Mar-Apr

REPOSITORIES: biostudies-literature