Synthesis and initial evaluation of radioactive 5-I-α-methyl-tryptophan: a Trp based agent targeting IDO-1.
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ABSTRACT:
SUBMITTER: Giglio BC
PROVIDER: S-EPMC6540958 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Publications
Synthesis and initial evaluation of radioactive 5-I-α-methyl-tryptophan: a Trp based agent targeting IDO-1.
Giglio Benjamin C BC Wang Hui H Yan Xuefeng X Li Zibo Z Li Zibo Z
MedChemComm 20190415 5
A synthetic approach is established to achieve radioactive 5-I-α-methyl-tryptophan (5-I-AMT). An enzyme based assay demonstrated that 5-I-AMT is a substrate of IDO-1. The <i>in vivo</i> distribution and imaging potential of 5-I-AMT were explored with a B16F10 tumor model using I-124 as the radiotag. ...[more]
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