Crystal-facet-dependent denitrosylation: modulation of NO release from S-nitrosothiols by Cu₂O polymorphs.

ABSTRACT: Nitric oxide (NO), a gaseous small molecule generated by the nitric oxide synthase (NOS) enzymes, plays key roles in signal transduction. The thiol groups present in many proteins and small molecules undergo nitrosylation to form the corresponding S-nitrosothiols. The release of NO from S-nitrosothiols is a key strategy to maintain the NO levels in biological systems. However, the controlled release of NO from the nitrosylated compounds at physiological pH remains a challenge. In this paper, we describe the synthesis and NO releasing ability of Cu₂O nanomaterials and provide the first experimental evidence that the nanocrystals having different crystal facets within the same crystal system exhibit different activities toward S-nitrosothiols. We used various

SUBMITTER: Ghosh S 

PROVIDER: S-EPMC6540961 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature