Impact of Regular Cannabis Use on Biomarkers of Lower Urinary Tract Function.

ABSTRACT:

Objective

To evaluate the differences in the composition and quantities of urine peptides in regular cannabis users and nonusers by liquid chromatography tandem mass spectrometry analysis.

Materials and methods

Urine specimens from healthy control subjects and cannabis users were utilized to identify the differences in the number and quantity of urine proteins by liquid chromatography tandem mass spectrometry analysis. Significantly altered proteins were determined by a permutation testing statistical method. Heat map, dendrogram, pathway, and network analyses were performed to assess the degree of expression and the potential relationships between proteins in both groups.

Results

A total of 1337 proteins were detected in both groups with 19 proteins being significant

SUBMITTER: Nedumaran B 

PROVIDER: S-EPMC6541002 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature