Luminal Plasma Treatment for Small Diameter Polyvinyl Alcohol Tubular Scaffolds.

ABSTRACT: Plasma-based surface modification is recognized as an effective way to activate biomaterial surfaces, and modulate their interactions with cells, extracellular matrix proteins, and other materials. However, treatment of a luminal surface of a tubular scaffold remains non-trivial to perform in small diameter tubes. Polyvinyl alcohol (PVA) hydrogel, which has been widely used for medical applications, lacks functional groups to mediate cell attachment. This poses an issue for vascular applications, as endothelialization in a vascular graft lumen is crucial to maintain long term graft patency. In this study, a Radio Frequency Glow Discharges (RFGD) treatment in the presence of NH₃ was used to modify the luminal surface of 3-mm diameter dehydrated PVA vascular grafts. The grafted ni

SUBMITTER: Pohan G 

PROVIDER: S-EPMC6541113 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature