Impairing the maintenance of germinative cells in Echinococcus multilocularis by targeting Aurora kinase.

ABSTRACT:

Background

The tumor-like growth of the metacestode larvae of the tapeworm E. multilocularis causes human alveolar echinococcosis, a severe disease mainly affecting the liver. The germinative cells, a population of adult stem cells, are crucial for the larval growth and development of the parasite within the hosts. Maintenance of the germinative cell pools relies on their abilities of extensive proliferation and self-renewal, which requires accurate control of the cell division cycle. Targeting regulators of the cell division progression may impair germinative cell populations, leading to impeded parasite growth.

Methodology/principal findings

In this study, we describe the characterization of EmAURKA and EmAURKB, which display significant similarity to the members of Aurora

SUBMITTER: Cheng Z 

PROVIDER: S-EPMC6541280 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature