Experimentally-constrained biophysical models of tonic and burst firing modes in thalamocortical neurons.

ABSTRACT: Somatosensory thalamocortical (TC) neurons from the ventrobasal (VB) thalamus are central components in the flow of sensory information between the periphery and the cerebral cortex, and participate in the dynamic regulation of thalamocortical states including wakefulness and sleep. This property is reflected at the cellular level by the ability to generate action potentials in two distinct firing modes, called tonic firing and low-threshold bursting. Although the general properties of TC neurons are known, we still lack a detailed characterization of their morphological and electrical properties in the VB thalamus. The aim of this study was to build biophysically-detailed models of VB TC neurons explicitly constrained with experimental data from rats. We recorded the electrical activity o

SUBMITTER: Iavarone E 

PROVIDER: S-EPMC6541309 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature