A three-component, Zn(OTf)₂-mediated entry into trisubstituted 2-aminoimidazoles.

ABSTRACT: A three-component reaction involving in situ generation of propargylureas and subsequent Zn(OTf)₂-mediated cyclocondensation with a primary amine yielded trisubstituted 2-aminoimidazoles. These findings are in contrast to the previously reported base-promoted unimolecular cyclization of propargylureas (leading to 2-imidazolones) and extend the range of Lewis acid-catalyzed azole syntheses based on N-carbonyl propargylamines.

SUBMITTER: Lukin A 

PROVIDER: S-EPMC6541334 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature