Enhanced inhibition of influenza virus infection by peptide-noble-metal nanoparticle conjugates.

ABSTRACT: The influenza ("flu") type-A virus is a major medical and veterinary health concern and causes global pandemics. The peptide "FluPep" is an established inhibitor of influenza virus infectivity in model systems. We have explored the potential for noble-metal nanoparticle conjugates of FluPep to enhance its antiviral activity and to determine their potential as a delivery platform for FluPep. FluPep ligand is FluPep extended at its N-terminus with the sequence CVVVTAAA, to allow for its incorporation into a mixed-matrix ligand shell of a peptidol and an alkanethiol ethylene glycol consisting of 70% CVVVTol and 30% HS(CH₂)₁₁(OC₂H₄)₄OH (mol/mol). Gold and silver nanoparticles (ca. 10 nm diameter) with up to 5% (mol/mol) FluPep ligand remai

SUBMITTER: Alghrair ZK 

PROVIDER: S-EPMC6541353 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature