Serum type and concentration both affect the protein-corona composition of PLGA nanoparticles.

ABSTRACT: Background: When nanoparticles (NPs) are applied into a biological fluid, such as blood, proteins bind rapidly to their surface forming a so-called "protein corona". These proteins are strongly attached to the NP surface and confers them a new biological identity that is crucial for the biological response in terms of body biodistribution, cellular uptake, and toxicity. The corona is dynamic in nature and it is well known that the composition varies in dependence of the physicochemical properties of the NPs. In the present study we investigated the protein corona that forms around poly(lactide-co-glycolide) (PLGA) NPs at different serum concentrations using two substantially different serum types, namely fetal bovine serum (FBS) and human serum. The corona was characterized b

SUBMITTER: Partikel K 

PROVIDER: S-EPMC6541368 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature