Analysis of differential gene expression mediated by clozapine in human postmortem brains.

ABSTRACT: Clozapine is the only medication indicated for treating refractory schizophrenia, due to its superior efficacy among all antipsychotic agents, but its mechanism of action is poorly understood. To date, no studies of human postmortem brain have characterized the gene expression response to clozapine. Therefore, we addressed this question by analyzing expression data extracted from published microarray studies involving brains of patients on antipsychotic therapy. We first performed a systematic review and identified four microarray studies of postmortem brains from antipsychotic-treated patients, then extracted the expression data. We then performed generalized linear model analysis on each study separately, and identified the genes differentially expressed in response to clozapine compared

SUBMITTER: Lee BJ 

PROVIDER: S-EPMC6541388 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature