Cardiac Valve Bioreactor for Physiological Conditioning and Hydrodynamic Performance Assessment.

ABSTRACT:

Purpose

Tissue engineered heart valves (TEHV) are being investigated to address the limitations of currently available valve prostheses. In order to advance a wide variety of TEHV approaches, the goal of this study was to develop a cardiac valve bioreactor system capable of conditioning living valves with a range of hydrodynamic conditions as well as capable of assessing hydrodynamic performance to ISO 5840 standards.

Methods

A bioreactor system was designed based on the Windkessel approach. Novel features including a purpose-built valve chamber and pressure feedback control were incorporated to maintain asepsis while achieving a range of hydrodynamic conditions. The system was validated by testing hydrodynamic conditions with a bioprosthesis and by operating with cell cultu

SUBMITTER: Tefft BJ 

PROVIDER: S-EPMC6541400 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature