Natural history of benign ethnic neutropenia in individuals of African ancestry.

ABSTRACT:

Background

Benign ethnic neutropenia (BEN), defined by neutrophil count <1.5 k/μL in the absence of other causes, is an asymptomatic condition more commonly observed in individuals of African ancestry. However, the natural history of this condition has been less well described.

Methods

Individuals with BEN were retrospectively identified by chart review or referral to hematology clinics. They were then invited to enroll in a prospective natural history study. Retrospective and prospective clinical and laboratory data were combined for descriptive analyses.

Findings

46 participants, younger and older adults from 2 institutions, had BEN. Hypertension was reported in 30%, musculoskeletal disorders in 15%, and upper respiratory infection in 33% of these adults. Their leuk

SUBMITTER: Lakhotia R 

PROVIDER: S-EPMC6541485 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature