Metabolomics reveals diet-derived plant polyphenols accumulate in physiological bone.

ABSTRACT: Plant-derived secondary metabolites consumed in the diet, especially polyphenolic compounds, are known to have a range of positive health effects. They are present in circulation after ingestion and absorption and can be sequestered into cells within particular organs, but have rarely been investigated systematically in osteological tissues. However, a small number of polyphenols and similar molecules are known to bind to bone. For example alizarin, a plant derived anthraquinone and tetracycline (a naturally occurring antibiotic), are both absorbed into bone from circulation during bone formation and are used to monitor mineralization in osteological studies. Both molecules have also been identified serendipitously in archaeological human bones derived from natural sources in the diet. Whe

SUBMITTER: Alldritt I 

PROVIDER: S-EPMC6541599 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature