Ep400 deficiency in Schwann cells causes persistent expression of early developmental regulators and peripheral neuropathy.

ABSTRACT: Schwann cells ensure efficient nerve impulse conduction in the peripheral nervous system. Their development is accompanied by defined chromatin changes, including variant histone deposition and redistribution. To study the importance of variant histones for Schwann cell development, we altered their genomic distribution by conditionally deleting Ep400, the central subunit of the Tip60/Ep400 complex. Ep400 absence causes peripheral neuropathy in mice, characterized by terminal differentiation defects in myelinating and non-myelinating Schwann cells and immune cell activation. Variant histone H2A.Z is differently distributed throughout the genome and remains at promoters of Tfap2a, Pax3 and other transcriptional regulator genes with transient function at earlier developmental stages. Tfap2a

SUBMITTER: Frob F 

PROVIDER: S-EPMC6541636 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature