Selective cell death of latently HIV-infected CD4⁺ T cells mediated by autosis inducing nanopeptides.

ABSTRACT: Despite significant advances in the treatment of human immunodeficiency virus type-1 (HIV) infection, antiretroviral therapy only suppresses viral replication but is unable to eliminate infection. Thus, discontinuation of antiretrovirals results in viral reactivation and disease progression. A major reservoir of HIV latent infection resides in resting central memory CD4⁺ T cells (T_CM) that escape clearance by current therapeutic regimens and will require novel strategies for elimination. Here, we evaluated the therapeutic potential of autophagy-inducing peptides, Tat-Beclin 1 and Tat-vFLIP-α2, which can induce a novel Na⁺/K⁺-ATPase dependent form of cell death (autosis), to kill latently HIV-infected T_CM while preventing virologic rebo

SUBMITTER: Zhang G 

PROVIDER: S-EPMC6541658 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature